State Police said one person was killed in a multi-vehicle crash that involved a tractor-trailer on Interstate 495 near Methuen.
State Police said the crash, which happened just after 3:30 p.m., involved four vehicles on the southbound side of Interstate 495 near 213 in Methuen.
One victim was pronounced dead shortly after rescue crews arrived at the scene. A second victim was airlifted to the hospital with life-threatening injuries.
Part of a car appeared to collide with a tractor-trailer, but it was not immediately clear what caused the accident.
SLIDESHOW: Photos from the scene
Interstate 495 was closed on both the northbound and southbound sides for approximately 45 minutes as the medical helicopter transported the victim to the hospital.
Interstate 495 southbound remained closed until 7pm Friday evening.
Extensive delays were reported in both directions in the area for hours after the accident.